Sponsored Content
FERTIBIOME® | EVIDENCIA CLÍNICA (1): PAREJAS EN TRATAMIENTO DE REPRODUCCIÓN ASISTIDA
9 Mar 2025Ligilactobacillus salivarius PS11610 ejerce un efecto sobre el perfil microbiano e inmunológico de parejas con infertilidad desconocida.
Estudio realizado en 2020 por el Hospital Universitario La Paz, Madrid (España). Publicado en American Journal of Reproductive Immunology, 2022.
Registrado en Clinicaltrials.gov
Abstract
Problem
Unknown or idiopathic infertility has been associated with urogenital tract dysbiosis, reducing pregnancy and delivery ratios during assisted reproductive treatments (ART). The Ligilactobacillus salivarius PS11610 strain has shown extraordinary antimicrobial activity in vitro against urogenital pathogens as well as other probiotic characteristics. Therefore, an intervention study was performed to evaluate the effect of L. salivarius PS11610 on the microbial composition of urogenital tract in infertile couples with bacterial dysbiosis.
Method of study
Seventeen couples undergoing ART diagnosed with unknown infertility were selected. After confirming urogenital dysbiosis, they started a 6-month treatment with L. salivarius PS11610 (1 dose/12 h for female and 1 dose/24 h for male). Vaginal, seminal, glans, uterine and plasma samples were collected for determination of the microbiome and immune profile at the beginning and the end of the treatment.
Results
Supplementation with L. salivarius PS11610 significantly modified the urogenital microbiome composition in male and female samples, solving dysbiosis of 67% of the couples. Pathogens disappeared from the vaginal samples whereas Lactobacilli percentage increased after 3 and 6 months of treatment. Moreover, L. salivarius PS11610 changed the uterine microbiome that could be associated with a change of the uterine immune profile. Additionally, the probiotic intake could be associated with the observed change in the systemic immunological profile of couples. Finally, the pregnant and delivery ratio were improved.
Conclusions
Probiotic supplementation with L. salivarius PS11610 improved the male and female urogenital tract microbiome, modulating the immune system and increasing pregnancy success in couples undergoing ART.
Companies mentioned
Related categories
Related news
Rioja Nature Pharma obtains Friend of the Sea certification
1 Apr 2025
Rioja
Nature Pharma takes another step forward in its commitment to excellence and
the environment by obtaining Friend of the Sea certification for its Omega-3
EPA and Omega-3 DHA softgel fish oil food supplement manufacturing lines.
New high-CBD raw material brings opportunities for the nutraceuticals industry
26 Mar 2025
A new high-CBD raw material is available to the nutraceuticals industry. Bedrocan, an experienced cannabis cultivator, explains why non-hemp CBD of consistent content is an advantage.
Read more
Rioja Nature Pharma incorporates Sulphoraphan Smart, an innovative compound patented by Ingredalia, to its catalogue of ingredients.
25 Mar 2025
Sulforaphane is the active ingredient of broccoli that makes this vegetable a superfood, as it activates the cellular defence against inflammation and oxidation. However, its synthesis and absorption is not always correct, as it is degraded before reac...
Read more
Faster, higher, better – Unlock the Power of Mineral Salts in Sports Nutrition
20 Mar 2025
Calcium, Iron, Magnesium, and Zinc fuel athletes' energy and recovery. German manufacturer Dr. Paul Lohmann® provides high-quality Mineral Salts that support peak athletic performance.
Read more
Visit MÜNZING at VITAFOODS 2025 in Barcelona, Spain at booth 5H45
18 Mar 2025
Experience MÜNZING's high-performance MAGRABAR® defoamers at Vitafoods Europe 2025, taking place from 20 to 22 May in Barcelona, Spain. Visit us at booth 5H45 for live demonstrations of our food-grade antifoams and insights into our i...
Read more
FrieslandCampina Ingredients launches Nutri Whey™ ProHeat for the performance and active nutrition market
18 Mar 2025
[18 March 2025] – FrieslandCampina Ingredients, a global leader in proteins and prebiotics, announces the launch of Nutri Whey™ ProHeat – a heat-stable whey protein – to help brands in the performance and active nutrition market...
Read more
Trend alert: photoprotection supplements
18 Mar 2025
The photoprotection market is evolving. More and more consumers are looking for innovative solutions to complement traditional sunscreens, and this is where food supplements with active photoprotective ingredients are making a difference.
Read more
Experts recommended treatment for knee osteoarthritis
17 Mar 2025
Artroveron® Active+ is a complex that helps to repair cartilage and maintain healthy joint so you can continue with daily activities such as walking, climbing stairs, getting out of bed without pain. Artroveron consists of high dose glucosami...
Read more
Protein Powders with Improved Solubility
14 Mar 2025
The clear advantages of fluidized bed technology compared to the drying process of protein powder in the spray tower:- Faster and improved solubility of proteins compared to powders from the spray tower
- Targeted adjustment of the particle size, re...
PharmaLinea's product awarded for innovation in bone and joint health
11 Mar 2025